Pharmacokinetics

Answers to key questions from experts here at Lundbeck

Here are answers to some of the most common questions concerning Cipralex. For more specific questions, we invite you to Ask an Expert here at Lundbeck. Our Medical Advisers are always happy to help.

Is the absorption of escitalopram affected by food intake?

No, absorption is unaffected by food. In practice: escitalopram can be...

How quickly is steady state reached?

Steady state, i.e., constant, plasma concentration, is theoretically reached...

What is the half-life (T1/2) of escitalopram?

The half-life is about 30 hours. In the elderly, the half-life is...

What is the bioavailability of escitalopram?

Absorption is almost complete, with limited first-pass metabolic loss, which is reflected in a...

How is escitalopram metabolised?

Escitalopram is metabolised by the cytochrome P450 enzymes, CYP3A4, 2C19 and 2D6, to its main...

Does escitalopram inhibit the CYP450 enzymes?

Escitalopram and its demethyl metabolite are both weak or negligible inhibitors of human hepatic enzyme systems...

Does escitalopram change (interconvert) to R-citalopram after intake?

Different studies have shown that no interconversion takes place. If, after (oral) intake, escitalopram converted...

How is escitalopram eliminated?

Renal elimination represents the major route of elimination for escitalopram and...

How important is plasma protein binding?

Plasma protein binding is moderate – below 80% (Guttierez & Mengel, 2002). Drug interactions between...

Last updated: 31.07.2008
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