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Key Publications

Unique Serotonin Dual-Action

The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors.

Chen F. et al. Eur Neuropsychopharmacol 2005; 15(2):193-198

Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram

Kasper S. et al. Int Clin Psychopharmacol 2009; 24(3):119-125

In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in Healthy subjects administered different doses of escitalopram or citalopram

Klein N. et al. Psychopharmacol 2006; 188(3):263-272

Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study

Klein N. et al. Psychopharmacol 2007; 191:(2)333-339

The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of s-citalopram

Sanchez C. Basic Clin Pharmacol Toxicol 2006; 99(2):91-95

Escitalopram versus citalopram: the surprising role of the R-enantiomer

Sanchez C. et al. Psychopharmacology 2004; 174(2):163-176

R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter

Stórustovu S. et al. Br J Pharmacol 2004; 142(1):172-180

Published: 23/05/2006 Last updated: 02/01/2012

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