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Key publications

Unique Serotonin Dual-Action

The S-enantiomer of R,S-citalopram, increases inhibitor binding to the human serotonin transporter by an allosteric mechanism. Comparison with other serotonin transporter inhibitors.

Chen et al., Eur Neuropsychopharmacol. 2005 Mar;15(2):193-8.

Differences in the dynamics of serotonin reuptake transporter occupancy may explain superior clinical efficacy of escitalopram versus citalopram

Kasper et al Int Clin Psychopharmacol 2009; 24: 119-125

In vivo imaging of serotonin transporter occupancy by means of SPECT and [123I]ADAM in Healthy subjects administered different doses of escitalopram or citalopram

Klien et al. Psychopharmacol 2006; 188: 263-272

Higher serotonin transporter occupancy after multiple dose administration of escitalopram compared to citalopram: an [123I]ADAM SPECT study

Klein et al. Psychopharmacol 2007; 191: 333-339

The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of s-citalopram

Sanchez C, Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):91-5

Escitalopram versus citalopram: the surprising role of the R-enantiomer

Sanchez et al., Psychopharmacology 2004; 174: 163-176

R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter

Stórustovu et al., British Journal of Pharmacology 2004; 142: 172-180

Published: 23/05/2006 Last updated: 27/07/2010

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