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Cipralex vs. venlafaxine XR

Cipralex works faster than venlafaxine XR (ref.1)

  • Cipralex offers earlier response and more patients achieved sustained remission in weeks 2-8 compared with venlafaxine XR.
  • Cipralex treated patients achieved sustained remission 6 days earlier than venlafaxine XR treated patients.
  • Furthermore Cipralex has a superior tolerability profile compared with venlafaxine XR and may thus possess a better benefit-risk profile.

Patients in sustained remission (%)

Percentage of patients treated with escitalopram and venlafaxine xr 75–150 mg/day in sustained remission during an 8-week period. A larger proportion of escitalopram-treated patients achieved sustained remission at weeks 2–8 (logistic regression, including factors for treatment, centre and baseline MADRS score). Sustained remission was defined as patients in remission (MADRS≥12) that was maintained until week 8.

Patients in remission at week 8 (%)

Plot of number of patients in remission from each treatment group as a percentage of the total number of patients in remission at week 8. Escitalopram-treated patients achieving remission at week 8 achieved sustained remission 6.6 days faster than venlafaxine wr-treated patients. The dotted lines indicate median time to achieve remission.

References:

1. Montgomery et al. 2004

Published: 05/05/2006   Last updated: 02/01/2012
 
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